Common Genetic Variation in IGF1 and Prostate Cancer Risk in the Multiethnic Cohort

Background: Insulin-like growth factor I (IGF-I) appears to play a role in prostate development and carcinogenesis. We investigated whether genetic variation at the IGF1 locus is associated with prostate cancer risk. Methods: We sequenced IGF1 exons in germline DNA from 95 men with advanced prostate...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2006-01, Vol.98 (2), p.123-134
Hauptverfasser:	Cheng, Iona, Stram, Daniel O., Penney, Kathryn L., Pike, Malcolm, Le Marchand, Loïc, Kolonel, Laurence N., Hirschhorn, Joel, Altshuler, David, Henderson, Brian E., Freedman, Matthew L.
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans - statistics & numerical data Aged Asian Americans - statistics & numerical data Biological and medical sciences Case-Control Studies Confidence Intervals Deoxyribonucleic acid DNA Ethnic Groups - statistics & numerical data European Continental Ancestry Group - statistics & numerical data Gene loci Genotype Genotype & phenotype Haplotypes Heredity Hispanic Americans - statistics & numerical data Humans Insulin-Like Growth Factor I - genetics Linkage Disequilibrium Logistic Models Male Medical sciences Nephrology. Urinary tract diseases Odds Ratio Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - epidemiology Prostatic Neoplasms - ethnology Prostatic Neoplasms - genetics Risk Assessment Risk factors Tumors Tumors of the urinary system United States - epidemiology Urinary tract. Prostate gland
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