Phosphatidylinositol 3-Kinase Inhibition by LY294002 Radiosensitizes Human Cervical Cancer Cell Lines

Purpose: The phosphatidylinositol 3-kinase (PI3K) catalytic subunit is amplified in cervical cancers, implicating PI3K in cervical carcinogenesis. We evaluated the radiosensitizing effect of PI3K inhibition by LY294002 on clonogenic survival, growth characteristics, and gene expression in cervical c...

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Veröffentlicht in:	Clinical cancer research 2006-01, Vol.12 (1), p.250-256
Hauptverfasser:	LEE, Christopher M, FUHRMAN, Christa B, PLANELLES, Vicente, PELTIER, Morgan R, GAFFNEY, David K, SOISSON, Andrew P, DODSON, Mark K, TOLLEY, H. Dennis, GREEN, Christopher L, ZEMPOLICH, Karen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Blotting, Western Cell Survival - drug effects cervix carcinoma Chromones - pharmacology Enzyme Inhibitors - pharmacology Female Female genital diseases Flow Cytometry Gene Expression - drug effects Gynecology. Andrology. Obstetrics HeLa Cells Humans Medical sciences Morpholines - pharmacology Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - drug effects PI3K Radiation sensitizer Radiation-Sensitizing Agents - pharmacology Tumors Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - therapy
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