Aberrant activation of notch signaling in human breast cancer

A role for Notch signaling in human breast cancer has been suggested by both the development of adenocarcinomas in the murine mammary gland following pathway activation and the loss of Numb expression, a negative regulator of the Notch pathway, in a large proportion of breast carcinomas. However, it...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-02, Vol.66 (3), p.1517-1525
Hauptverfasser:	STYLIANOU, Spyros, CLARKE, Rob B, BRENNAN, Keith
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Biological and medical sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Transformation, Neoplastic - metabolism Epithelial Cells - metabolism Epithelial Cells - pathology Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Receptor, Notch1 - antagonists & inhibitors Receptor, Notch1 - metabolism Receptors, Notch - metabolism Signal Transduction Tumors
Online-Zugang:	Volltext
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