Role of spinal 5-HT5A , and 5-HT1A/1B/1D , receptors in neuropathic pain induced by spinal nerve ligation in rats

Abstract Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT receptors. The role of 5-HT5A receptor in neuropathic pain has not previously studied. The purpose of this study was to investigate: A) the role of 5-HT5A receptors in rats subjected to spinal nerve injury;...

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Veröffentlicht in:	Brain research 2015-10, Vol.1622, p.377-385
Hauptverfasser:	Avila-Rojas, Sabino Hazael, Velázquez-Lagunas, Isabel, Salinas-Abarca, Ana Belen, Barragán-Iglesias, Paulino, Pineda-Farias, Jorge Baruch, Granados-Soto, Vinicio
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT5A receptors Analgesics - pharmacology Animals Dose-Response Relationship, Drug Female Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Hyperalgesia - drug therapy Hyperalgesia - metabolism Lumbar Vertebrae Methiothepin - pharmacology Neuralgia - drug therapy Neuralgia - metabolism Neurology Neuropathy Oxadiazoles - pharmacology Piperazines - pharmacology Pyridines - pharmacology Rats, Wistar Receptor, Serotonin, 5-HT1A - metabolism Receptor, Serotonin, 5-HT1B - metabolism Receptor, Serotonin, 5-HT1D - metabolism Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT1 - metabolism Serotonin Serotonin - analogs & derivatives Serotonin - pharmacology Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Spinal cord Spinal Cord - drug effects Spinal Cord - metabolism Spinal Nerves - injuries Tactile allodynia Touch
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