PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation

Pluripotency and self-renewal of mouse embryonic stem cells (ESCs) depend on a network of transcription factors maintained by exogenous leukaemia inhibitory factor (LIF). PR-domain containing transcriptional regulator 14 (PRDM14), is essential for maintenance of ESC self-renewal when the cells are c...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-10, Vol.466 (1), p.138-145
Hauptverfasser:	Okashita, Naoki, Sakashita, Nao, Ito, Ken, Mitsuya, Ayaka, Suwa, Yoshiaki, Seki, Yoshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Proliferation DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Gene Expression Regulation Gene Knockout Techniques Leukemia Inhibitory Factor - metabolism LIF Mice PRDM14 Primordial germ cells Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Self-renewal Transcription Factors - genetics Transcription Factors - metabolism Up-Regulation
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