Salivary antibody levels in adolescents in response to a meningococcal serogroup C conjugate booster vaccination nine years after priming: systemically induced local immunity and saliva as potential surveillance tool
Abstract Background In several countries large-scale immunization of children and young adults with Meningococcal serogroup C (MenC) conjugate vaccines has induced long-standing herd protection. Salivary antibodies may play an important role in mucosal protection against meningococcal acquisition an...
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| Veröffentlicht in: | Vaccine 2015-07, Vol.33 (32), p.3933-3939 |
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| creator | Stoof, Susanne P van der Klis, Fiona R.M van Rooijen, Debbie M Bogaert, Debby Trzciński, Krzysztof Sanders, Elisabeth A.M Berbers, Guy A.M |
| description | Abstract Background In several countries large-scale immunization of children and young adults with Meningococcal serogroup C (MenC) conjugate vaccines has induced long-standing herd protection. Salivary antibodies may play an important role in mucosal protection against meningococcal acquisition and carriage. Aim To investigate antibody levels in (pre)adolescents primed 9 years earlier with a single dose of MenC-polysaccharide tetanus toxoid conjugated (MenC-TT) vaccine and the response to a booster vaccination, with special focus on age-related differences and the relation between salivary and serum antibody levels. Methods Nine years after priming, healthy 10- ( n = 91), 12- ( n = 91) and 15-year-olds ( n = 86) received a MenC-TT booster vaccination. Saliva and serum samples were collected prior to and 1 month and 1 year after vaccination. MenC-polysaccharide(MenC-PS)-specific antibody levels were measured using a fluorescent-bead-based multiplex immunoassay. Results Before the booster, MenC-PS-specific IgG and IgA levels in saliva and serum were low and correlated with age at priming. The booster induced a marked increase in salivary MenC-PS-specific IgG (>200-fold), but also in IgA (∼10-fold). One year after the booster, salivary IgG and IgA had remained above pre-booster levels in all age groups (∼20-fold and ∼3-fold, respectively), with persistence of highest levels in the 15-year-olds. MenC-PS-specific IgG and IgA levels in saliva strongly correlated with the levels in serum. Conclusion Parenteral MenC-TT booster vaccination induces a clear increase in salivary MenC-PS-specific IgG and IgA levels and persistence of highest levels correlates with age. The strong correlation between serum and salivary antibody levels indicate that saliva may offer an easy and reliable tool for future antibody surveillance. |
| doi_str_mv | 10.1016/j.vaccine.2015.06.055 |
| format | Article |
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Salivary antibodies may play an important role in mucosal protection against meningococcal acquisition and carriage. Aim To investigate antibody levels in (pre)adolescents primed 9 years earlier with a single dose of MenC-polysaccharide tetanus toxoid conjugated (MenC-TT) vaccine and the response to a booster vaccination, with special focus on age-related differences and the relation between salivary and serum antibody levels. Methods Nine years after priming, healthy 10- ( n = 91), 12- ( n = 91) and 15-year-olds ( n = 86) received a MenC-TT booster vaccination. Saliva and serum samples were collected prior to and 1 month and 1 year after vaccination. MenC-polysaccharide(MenC-PS)-specific antibody levels were measured using a fluorescent-bead-based multiplex immunoassay. Results Before the booster, MenC-PS-specific IgG and IgA levels in saliva and serum were low and correlated with age at priming. The booster induced a marked increase in salivary MenC-PS-specific IgG (>200-fold), but also in IgA (∼10-fold). One year after the booster, salivary IgG and IgA had remained above pre-booster levels in all age groups (∼20-fold and ∼3-fold, respectively), with persistence of highest levels in the 15-year-olds. MenC-PS-specific IgG and IgA levels in saliva strongly correlated with the levels in serum. Conclusion Parenteral MenC-TT booster vaccination induces a clear increase in salivary MenC-PS-specific IgG and IgA levels and persistence of highest levels correlates with age. The strong correlation between serum and salivary antibody levels indicate that saliva may offer an easy and reliable tool for future antibody surveillance.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2015.06.055</identifier><identifier>PMID: 26100925</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Adolescent booster ; Adolescents ; Age ; Allergy and Immunology ; Antibodies, Bacterial - analysis ; Antibodies, Bacterial - blood ; Child ; Child, Preschool ; Epidemiological Monitoring ; Female ; Humans ; Immunization ; Immunization, Secondary ; Immunoglobulin A - analysis ; Immunoglobulin A - blood ; Immunoglobulin G - analysis ; Immunoglobulin G - blood ; Immunoglobulins ; Infant ; Male ; Meningitis ; Meningococcal serogroup C conjugate vaccine ; Meningococcal Vaccines - administration & dosage ; Meningococcal Vaccines - immunology ; Neisseria meningitidis ; Neisseria meningitidis, Serogroup C - immunology ; Population ; Saliva - chemistry ; Saliva - immunology ; Salivary antibodies ; Serum - chemistry ; Serum - immunology ; Streptococcus infections ; Surveillance ; Surveillance tool ; Teenagers ; Vaccines ; Vaccines, Conjugate - administration & dosage ; Vaccines, Conjugate - immunology ; Young adults</subject><ispartof>Vaccine, 2015-07, Vol.33 (32), p.3933-3939</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jul 31, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-aed4485a40be8463e50270b915c21858a033d394cc5d9bd55c7528076bbf97513</citedby><cites>FETCH-LOGICAL-c547t-aed4485a40be8463e50270b915c21858a033d394cc5d9bd55c7528076bbf97513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X15008440$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26100925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stoof, Susanne P</creatorcontrib><creatorcontrib>van der Klis, Fiona R.M</creatorcontrib><creatorcontrib>van Rooijen, Debbie M</creatorcontrib><creatorcontrib>Bogaert, Debby</creatorcontrib><creatorcontrib>Trzciński, Krzysztof</creatorcontrib><creatorcontrib>Sanders, Elisabeth A.M</creatorcontrib><creatorcontrib>Berbers, Guy A.M</creatorcontrib><title>Salivary antibody levels in adolescents in response to a meningococcal serogroup C conjugate booster vaccination nine years after priming: systemically induced local immunity and saliva as potential surveillance tool</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Background In several countries large-scale immunization of children and young adults with Meningococcal serogroup C (MenC) conjugate vaccines has induced long-standing herd protection. Salivary antibodies may play an important role in mucosal protection against meningococcal acquisition and carriage. Aim To investigate antibody levels in (pre)adolescents primed 9 years earlier with a single dose of MenC-polysaccharide tetanus toxoid conjugated (MenC-TT) vaccine and the response to a booster vaccination, with special focus on age-related differences and the relation between salivary and serum antibody levels. Methods Nine years after priming, healthy 10- ( n = 91), 12- ( n = 91) and 15-year-olds ( n = 86) received a MenC-TT booster vaccination. Saliva and serum samples were collected prior to and 1 month and 1 year after vaccination. MenC-polysaccharide(MenC-PS)-specific antibody levels were measured using a fluorescent-bead-based multiplex immunoassay. Results Before the booster, MenC-PS-specific IgG and IgA levels in saliva and serum were low and correlated with age at priming. The booster induced a marked increase in salivary MenC-PS-specific IgG (>200-fold), but also in IgA (∼10-fold). One year after the booster, salivary IgG and IgA had remained above pre-booster levels in all age groups (∼20-fold and ∼3-fold, respectively), with persistence of highest levels in the 15-year-olds. MenC-PS-specific IgG and IgA levels in saliva strongly correlated with the levels in serum. Conclusion Parenteral MenC-TT booster vaccination induces a clear increase in salivary MenC-PS-specific IgG and IgA levels and persistence of highest levels correlates with age. The strong correlation between serum and salivary antibody levels indicate that saliva may offer an easy and reliable tool for future antibody surveillance.</description><subject>Adolescent</subject><subject>Adolescent booster</subject><subject>Adolescents</subject><subject>Age</subject><subject>Allergy and Immunology</subject><subject>Antibodies, Bacterial - analysis</subject><subject>Antibodies, Bacterial - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Epidemiological Monitoring</subject><subject>Female</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization, Secondary</subject><subject>Immunoglobulin A - analysis</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulins</subject><subject>Infant</subject><subject>Male</subject><subject>Meningitis</subject><subject>Meningococcal serogroup C conjugate vaccine</subject><subject>Meningococcal Vaccines - administration & dosage</subject><subject>Meningococcal Vaccines - immunology</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis, Serogroup C - immunology</subject><subject>Population</subject><subject>Saliva - chemistry</subject><subject>Saliva - immunology</subject><subject>Salivary antibodies</subject><subject>Serum - chemistry</subject><subject>Serum - immunology</subject><subject>Streptococcus infections</subject><subject>Surveillance</subject><subject>Surveillance tool</subject><subject>Teenagers</subject><subject>Vaccines</subject><subject>Vaccines, Conjugate - administration & dosage</subject><subject>Vaccines, Conjugate - immunology</subject><subject>Young adults</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks-KFDEQxhtR3HX1EZSAFy8zVro73WkPigz-gwUPq-AtpJOaIWM6GZP0QL-pj2OyMyrsZU8h5Kuvvqr8quo5hTUF2r3er49SKeNwXQNla-jWwNiD6pLyvlnVjPKH1SXUXbtqKfy4qJ7EuAcA1tDhcXVRdxRgqNll9ftGWnOUYSHSJTN6vRCLR7SRGEek9hajQpdurwHjwbuIJHkiyYTOuJ1XXilpScTgd8HPB7Ihyrv9vJMJyeh9TBjIKapMxjuSq5AsKEMkclseD8FM2ekNiUsWTybb2SX307NCTawv9maaZmdSSalJvI1MZCQHn3I4U_rP4YjGWulUyeft0-rRVtqIz87nVfX944dvm8-r66-fvmzeX68Ua_u0kqjbljPZwoi87RpkUPcwDpSpmnLGJTSNboZWKaaHUTOmelZz6Ltx3A49o81V9erkewj-14wxicnklZUk6OcoaN92fGB54_dLu6Hv2cDpkKUv70j3fg4uD5INgdOGD7TJKnZSqeBjDLgVZZf5MwUFUSgRe3GmRBRKBHQiU5LrXpzd53FC_a_qLxZZ8O4kyCDg0WAQURnMq9UmoEpCe3Nvi7d3HJQ1rvztT1ww_p9GxFqAuCmoFlIpA-BtC80fc7nqoA</recordid><startdate>20150731</startdate><enddate>20150731</enddate><creator>Stoof, Susanne P</creator><creator>van der Klis, Fiona R.M</creator><creator>van Rooijen, Debbie M</creator><creator>Bogaert, Debby</creator><creator>Trzciński, Krzysztof</creator><creator>Sanders, Elisabeth A.M</creator><creator>Berbers, Guy A.M</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150731</creationdate><title>Salivary antibody levels in adolescents in response to a meningococcal serogroup C conjugate booster vaccination nine years after priming: systemically induced local immunity and saliva as potential surveillance tool</title><author>Stoof, Susanne P ; van der Klis, Fiona R.M ; van Rooijen, Debbie M ; Bogaert, Debby ; Trzciński, Krzysztof ; Sanders, Elisabeth A.M ; Berbers, Guy A.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-aed4485a40be8463e50270b915c21858a033d394cc5d9bd55c7528076bbf97513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adolescent booster</topic><topic>Adolescents</topic><topic>Age</topic><topic>Allergy and Immunology</topic><topic>Antibodies, Bacterial - analysis</topic><topic>Antibodies, Bacterial - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Epidemiological Monitoring</topic><topic>Female</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization, Secondary</topic><topic>Immunoglobulin A - analysis</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulins</topic><topic>Infant</topic><topic>Male</topic><topic>Meningitis</topic><topic>Meningococcal serogroup C conjugate vaccine</topic><topic>Meningococcal Vaccines - administration & dosage</topic><topic>Meningococcal Vaccines - immunology</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis, Serogroup C - immunology</topic><topic>Population</topic><topic>Saliva - chemistry</topic><topic>Saliva - immunology</topic><topic>Salivary antibodies</topic><topic>Serum - chemistry</topic><topic>Serum - immunology</topic><topic>Streptococcus infections</topic><topic>Surveillance</topic><topic>Surveillance tool</topic><topic>Teenagers</topic><topic>Vaccines</topic><topic>Vaccines, Conjugate - administration & dosage</topic><topic>Vaccines, Conjugate - immunology</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stoof, Susanne P</creatorcontrib><creatorcontrib>van der Klis, Fiona R.M</creatorcontrib><creatorcontrib>van Rooijen, Debbie M</creatorcontrib><creatorcontrib>Bogaert, Debby</creatorcontrib><creatorcontrib>Trzciński, Krzysztof</creatorcontrib><creatorcontrib>Sanders, Elisabeth A.M</creatorcontrib><creatorcontrib>Berbers, Guy A.M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stoof, Susanne P</au><au>van der Klis, Fiona R.M</au><au>van Rooijen, Debbie M</au><au>Bogaert, Debby</au><au>Trzciński, Krzysztof</au><au>Sanders, Elisabeth A.M</au><au>Berbers, Guy A.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary antibody levels in adolescents in response to a meningococcal serogroup C conjugate booster vaccination nine years after priming: systemically induced local immunity and saliva as potential surveillance tool</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2015-07-31</date><risdate>2015</risdate><volume>33</volume><issue>32</issue><spage>3933</spage><epage>3939</epage><pages>3933-3939</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Abstract Background In several countries large-scale immunization of children and young adults with Meningococcal serogroup C (MenC) conjugate vaccines has induced long-standing herd protection. Salivary antibodies may play an important role in mucosal protection against meningococcal acquisition and carriage. Aim To investigate antibody levels in (pre)adolescents primed 9 years earlier with a single dose of MenC-polysaccharide tetanus toxoid conjugated (MenC-TT) vaccine and the response to a booster vaccination, with special focus on age-related differences and the relation between salivary and serum antibody levels. Methods Nine years after priming, healthy 10- ( n = 91), 12- ( n = 91) and 15-year-olds ( n = 86) received a MenC-TT booster vaccination. Saliva and serum samples were collected prior to and 1 month and 1 year after vaccination. MenC-polysaccharide(MenC-PS)-specific antibody levels were measured using a fluorescent-bead-based multiplex immunoassay. Results Before the booster, MenC-PS-specific IgG and IgA levels in saliva and serum were low and correlated with age at priming. The booster induced a marked increase in salivary MenC-PS-specific IgG (>200-fold), but also in IgA (∼10-fold). One year after the booster, salivary IgG and IgA had remained above pre-booster levels in all age groups (∼20-fold and ∼3-fold, respectively), with persistence of highest levels in the 15-year-olds. MenC-PS-specific IgG and IgA levels in saliva strongly correlated with the levels in serum. Conclusion Parenteral MenC-TT booster vaccination induces a clear increase in salivary MenC-PS-specific IgG and IgA levels and persistence of highest levels correlates with age. The strong correlation between serum and salivary antibody levels indicate that saliva may offer an easy and reliable tool for future antibody surveillance.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>26100925</pmid><doi>10.1016/j.vaccine.2015.06.055</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adolescent booster Adolescents Age Allergy and Immunology Antibodies, Bacterial - analysis Antibodies, Bacterial - blood Child Child, Preschool Epidemiological Monitoring Female Humans Immunization Immunization, Secondary Immunoglobulin A - analysis Immunoglobulin A - blood Immunoglobulin G - analysis Immunoglobulin G - blood Immunoglobulins Infant Male Meningitis Meningococcal serogroup C conjugate vaccine Meningococcal Vaccines - administration & dosage Meningococcal Vaccines - immunology Neisseria meningitidis Neisseria meningitidis, Serogroup C - immunology Population Saliva - chemistry Saliva - immunology Salivary antibodies Serum - chemistry Serum - immunology Streptococcus infections Surveillance Surveillance tool Teenagers Vaccines Vaccines, Conjugate - administration & dosage Vaccines, Conjugate - immunology Young adults |
| title | Salivary antibody levels in adolescents in response to a meningococcal serogroup C conjugate booster vaccination nine years after priming: systemically induced local immunity and saliva as potential surveillance tool |
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