Preclinical development of a dengue tetravalent recombinant subunit vaccine: Immunogenicity and protective efficacy in nonhuman primates

Highlights • Subunit DEN-80E protein was evaluated as monovalent and tetravalent formulations for immunogenicity and efficacy in non-human primates. • Monomeric and dimeric forms of DEN4-80E were found to be equally immunogenic/protective when formulated with ISCOMATRIX™ adjuvant. • Tetravalent DEN-...

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Veröffentlicht in:	Vaccine 2015-08, Vol.33 (33), p.4105-4116
Hauptverfasser:	Govindarajan, Dhanasekaran, Meschino, Steven, Guan, Liming, Clements, David E, ter Meulen, Jan H, Casimiro, Danilo R, Coller, Beth-Ann G, Bett, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Allergy and Immunology Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Cholesterol - administration & dosage Dengue Dengue - prevention & control Dengue fever Dengue Vaccines - administration & dosage Dengue Vaccines - immunology Disease Models, Animal Drug Combinations Drug Evaluation, Preclinical Efficacy Envelope Female Illnesses Immunization Immunization Schedule Immunogenicity Infections Insects Macaca mulatta Male Monkeys & apes Neutralization Phospholipids - administration & dosage Proteins Saponins - administration & dosage Subunit vaccine Tropical diseases Vaccines Vaccines, Combined - administration & dosage Vaccines, Combined - immunology Vaccines, Subunit - administration & dosage Vaccines, Subunit - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Vector-borne diseases Viremia - prevention & control Viruses
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