Transgenic Wuzhishan minipigs designed to express a dominant-negative porcine growth hormone receptor display small stature and a perturbed insulin/IGF-1 pathway

Growth hormone (GH) is an anabolic mitogen with widespread influence on cellular growth and differentiation as well as on glucose and lipid metabolism. GH binding to the growth hormone receptor (GHR) on hepatocytes prompts expression of insulin growth factor I (IGF-1) involved in nutritionally induc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transgenic research 2015-12, Vol.24 (6), p.1029-1042
Hauptverfasser:	Li, Feida, Li, Yong, Liu, Huan, Zhang, Xingju, Liu, Chuxin, Tian, Kai, Bolund, Lars, Dou, Hongwei, Yang, Wenxian, Yang, Huanming, Staunstrup, Nicklas Heine, Du, Yutao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Animals, Genetically Modified - genetics Animals, Genetically Modified - growth & development Animals, Genetically Modified - metabolism Biomedical and Life Sciences Biomedical Engineering/Biotechnology Female Genes, Dominant Genetic Engineering Humans Insulin - blood Insulin-Like Growth Factor I - metabolism Laron Syndrome - etiology Laron Syndrome - metabolism Laron Syndrome - pathology Life Sciences Molecular Medicine Original Paper Plant Genetics and Genomics Receptors, Somatotropin - genetics Receptors, Somatotropin - metabolism Signal Transduction Swine Swine, Miniature Transgenics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!