Growth/differentiation factor-15 and its role in peripheral nervous system lesion and regeneration

Growth/differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor beta (TGF-β) superfamily. It is widely distributed in the nervous system, where it has been shown to play an important role in neuronal maintenance. The present study investigates the role of endogenous G...

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Veröffentlicht in:	Cell and tissue research 2015-11, Vol.362 (2), p.317-330
Hauptverfasser:	Wang, Xiaolong, Krebbers, Julia, Charalambous, Petar, Machado, Venissa, Schober, Andreas, Bosse, Frank, Müller, Hans-Werner, Unsicker, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals axons Axons - metabolism Biomedical and Life Sciences Biomedicine cell death death electromyography ganglia Ganglia, Spinal - metabolism genotype Growth Differentiation Factor 15 - metabolism Human Genetics macrophage activation macrophages messenger RNA mice Mice, Inbred C57BL Mice, Transgenic Molecular Medicine Nerve Crush - methods Nerve Regeneration - genetics Nerve Regeneration - physiology nerve tissue Nervous system Neurophysiology peripheral nervous system Proteomics Regular Article RNA Sciatic Nerve - metabolism Studies superfamily Tissue engineering transforming growth factor beta Transforming Growth Factor beta - metabolism Transforming growth factors
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