Potential and limits of whole genome prediction of resistance to Fusarium head blight and Septoria tritici blotch in a vast Central European elite winter wheat population
Key message Fusarium head blight and Septoria tritici blotch resistances are complex traits and can be improved efficiently by genomic selection modeling main and epistatic effects. Enhancing the resistance against Fusarium head blight (FHB) and Septoria tritici blotch (STB) is of central importance...
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| Veröffentlicht in: | Theoretical and applied genetics 2015-12, Vol.128 (12), p.2471-2481 |
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| container_title | Theoretical and applied genetics |
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| creator | Mirdita, Vilson He, Sang Zhao, Yusheng Korzun, Viktor Bothe, Reiner Ebmeyer, Erhard Reif, Jochen C. Jiang, Yong |
| description | Key message
Fusarium head blight and
Septoria tritici blotch resistances are complex traits and can be improved efficiently by genomic selection modeling main and epistatic effects.
Enhancing the resistance against Fusarium head blight (FHB) and Septoria tritici blotch (STB) is of central importance for a sustainable wheat production. Our study is based on a large experimental data set of 2325 inbred lines genotyped with 12,642 SNP markers and phenotyped in multi-environmental trials for FHB and STB resistance as well as for plant height. Our objectives were to (1) investigate the impact of plant height on FHB and STB severity, (2) examine the potential of marker-assisted selection, and (3) study the prediction ability of genomic selection modeling main and epistatic effects. We observed low correlations between plant height and FHB (
r
= −0.15;
P
|
| doi_str_mv | 10.1007/s00122-015-2602-1 |
| format | Article |
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Fusarium head blight and
Septoria tritici blotch resistances are complex traits and can be improved efficiently by genomic selection modeling main and epistatic effects.
Enhancing the resistance against Fusarium head blight (FHB) and Septoria tritici blotch (STB) is of central importance for a sustainable wheat production. Our study is based on a large experimental data set of 2325 inbred lines genotyped with 12,642 SNP markers and phenotyped in multi-environmental trials for FHB and STB resistance as well as for plant height. Our objectives were to (1) investigate the impact of plant height on FHB and STB severity, (2) examine the potential of marker-assisted selection, and (3) study the prediction ability of genomic selection modeling main and epistatic effects. We observed low correlations between plant height and FHB (
r
= −0.15;
P
< 0.05) as well as STB severity (
r
= −0.17;
P
< 0.05) suggesting negligible morphological resistances. Cross-validation in combination with association mapping revealed absence of large effect QTL impeding an efficient pyramiding of different resistance loci through marker-assisted selection. The prediction ability of genomic selection was high amounting to 0.6 for FHB and 0.5 for STB resistance. Therefore, genomic selection is a promising tool to improve FHB and STB resistance in wheat.</description><identifier>ISSN: 0040-5752</identifier><identifier>EISSN: 1432-2242</identifier><identifier>DOI: 10.1007/s00122-015-2602-1</identifier><identifier>PMID: 26350496</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Agriculture ; Ascomycota ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Chromosome Mapping ; Disease Resistance - genetics ; Epistasis, Genetic ; Fungicides ; Fusarium ; Genomes ; Genotype ; Life Sciences ; Models, Genetic ; Original Article ; Pesticides ; Phenotype ; Plant Biochemistry ; Plant Breeding/Biotechnology ; Plant Diseases - genetics ; Plant Diseases - microbiology ; Plant Genetics and Genomics ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Selection, Genetic ; Septoria tritici ; Triticum - genetics ; Triticum - microbiology ; Triticum aestivum ; Wheat</subject><ispartof>Theoretical and applied genetics, 2015-12, Vol.128 (12), p.2471-2481</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c589t-31ed9ec3764bd2ad85b9ef7bb1d8ddac73d2936fe4b9a7aab067dc55be741dce3</citedby><cites>FETCH-LOGICAL-c589t-31ed9ec3764bd2ad85b9ef7bb1d8ddac73d2936fe4b9a7aab067dc55be741dce3</cites><orcidid>0000-0001-6098-1558</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00122-015-2602-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00122-015-2602-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26350496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mirdita, Vilson</creatorcontrib><creatorcontrib>He, Sang</creatorcontrib><creatorcontrib>Zhao, Yusheng</creatorcontrib><creatorcontrib>Korzun, Viktor</creatorcontrib><creatorcontrib>Bothe, Reiner</creatorcontrib><creatorcontrib>Ebmeyer, Erhard</creatorcontrib><creatorcontrib>Reif, Jochen C.</creatorcontrib><creatorcontrib>Jiang, Yong</creatorcontrib><title>Potential and limits of whole genome prediction of resistance to Fusarium head blight and Septoria tritici blotch in a vast Central European elite winter wheat population</title><title>Theoretical and applied genetics</title><addtitle>Theor Appl Genet</addtitle><addtitle>Theor Appl Genet</addtitle><description>Key message
Fusarium head blight and
Septoria tritici blotch resistances are complex traits and can be improved efficiently by genomic selection modeling main and epistatic effects.
Enhancing the resistance against Fusarium head blight (FHB) and Septoria tritici blotch (STB) is of central importance for a sustainable wheat production. Our study is based on a large experimental data set of 2325 inbred lines genotyped with 12,642 SNP markers and phenotyped in multi-environmental trials for FHB and STB resistance as well as for plant height. Our objectives were to (1) investigate the impact of plant height on FHB and STB severity, (2) examine the potential of marker-assisted selection, and (3) study the prediction ability of genomic selection modeling main and epistatic effects. We observed low correlations between plant height and FHB (
r
= −0.15;
P
< 0.05) as well as STB severity (
r
= −0.17;
P
< 0.05) suggesting negligible morphological resistances. Cross-validation in combination with association mapping revealed absence of large effect QTL impeding an efficient pyramiding of different resistance loci through marker-assisted selection. The prediction ability of genomic selection was high amounting to 0.6 for FHB and 0.5 for STB resistance. Therefore, genomic selection is a promising tool to improve FHB and STB resistance in wheat.</description><subject>Agriculture</subject><subject>Ascomycota</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Chromosome Mapping</subject><subject>Disease Resistance - genetics</subject><subject>Epistasis, Genetic</subject><subject>Fungicides</subject><subject>Fusarium</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Life Sciences</subject><subject>Models, Genetic</subject><subject>Original Article</subject><subject>Pesticides</subject><subject>Phenotype</subject><subject>Plant Biochemistry</subject><subject>Plant Breeding/Biotechnology</subject><subject>Plant Diseases - genetics</subject><subject>Plant Diseases - microbiology</subject><subject>Plant Genetics and Genomics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Quantitative Trait Loci</subject><subject>Selection, Genetic</subject><subject>Septoria tritici</subject><subject>Triticum - genetics</subject><subject>Triticum - microbiology</subject><subject>Triticum aestivum</subject><subject>Wheat</subject><issn>0040-5752</issn><issn>1432-2242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU-L1TAUxYMozvPpB3AjATduqvnTNO1SHjMqDCio63Kb3L6XoU1qkjr4lfyUpr5RRBBXd3F-95ybHEKecvaSM6ZfJca4EBXjqhINExW_R3a8lqISohb3yY6xmlVKK3FBHqV0wxgTismH5EI0UrG6a3bk-4eQ0WcHEwVv6eRmlxMNI709hQnpEX2YkS4RrTPZBb9JEZNLGbxBmgO9WhNEt870hGDpMLnjKf_0-ohLDtEBzdFlZ1zRQjYn6jwF-hVSpoeSHEvy5RrDguApTi4jvXU-YywXIGS6hGWdYIt-TB6MMCV8cjf35PPV5afD2-r6_Zt3h9fXlVFtlyvJ0XZopG7qwQqwrRo6HPUwcNtaC0ZLKzrZjFgPHWiAgTXaGqUG1DW3BuWevDj7LjF8WTHlfnbJ4DSBx7Cmnuu6aVvZlq_8PyqFZFqUwD15_hd6E9boy0M2ijeyUy0vFD9TJoaUIo79Et0M8VvPWb913p8770vn_dZ5v-08u3Nehxnt741fJRdAnIFUJH_E-Ef0P11_AN6tuog</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Mirdita, Vilson</creator><creator>He, Sang</creator><creator>Zhao, Yusheng</creator><creator>Korzun, Viktor</creator><creator>Bothe, Reiner</creator><creator>Ebmeyer, Erhard</creator><creator>Reif, Jochen C.</creator><creator>Jiang, Yong</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>M7N</scope><orcidid>https://orcid.org/0000-0001-6098-1558</orcidid></search><sort><creationdate>20151201</creationdate><title>Potential and limits of whole genome prediction of resistance to Fusarium head blight and Septoria tritici blotch in a vast Central European elite winter wheat population</title><author>Mirdita, Vilson ; He, Sang ; Zhao, Yusheng ; Korzun, Viktor ; Bothe, Reiner ; Ebmeyer, Erhard ; Reif, Jochen C. ; Jiang, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-31ed9ec3764bd2ad85b9ef7bb1d8ddac73d2936fe4b9a7aab067dc55be741dce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Agriculture</topic><topic>Ascomycota</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Chromosome Mapping</topic><topic>Disease Resistance - genetics</topic><topic>Epistasis, Genetic</topic><topic>Fungicides</topic><topic>Fusarium</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Life Sciences</topic><topic>Models, Genetic</topic><topic>Original Article</topic><topic>Pesticides</topic><topic>Phenotype</topic><topic>Plant Biochemistry</topic><topic>Plant Breeding/Biotechnology</topic><topic>Plant Diseases - genetics</topic><topic>Plant Diseases - microbiology</topic><topic>Plant Genetics and Genomics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Quantitative Trait Loci</topic><topic>Selection, Genetic</topic><topic>Septoria tritici</topic><topic>Triticum - genetics</topic><topic>Triticum - microbiology</topic><topic>Triticum aestivum</topic><topic>Wheat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mirdita, Vilson</creatorcontrib><creatorcontrib>He, Sang</creatorcontrib><creatorcontrib>Zhao, Yusheng</creatorcontrib><creatorcontrib>Korzun, Viktor</creatorcontrib><creatorcontrib>Bothe, Reiner</creatorcontrib><creatorcontrib>Ebmeyer, Erhard</creatorcontrib><creatorcontrib>Reif, Jochen C.</creatorcontrib><creatorcontrib>Jiang, Yong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Theoretical and applied genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mirdita, Vilson</au><au>He, Sang</au><au>Zhao, Yusheng</au><au>Korzun, Viktor</au><au>Bothe, Reiner</au><au>Ebmeyer, Erhard</au><au>Reif, Jochen C.</au><au>Jiang, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential and limits of whole genome prediction of resistance to Fusarium head blight and Septoria tritici blotch in a vast Central European elite winter wheat population</atitle><jtitle>Theoretical and applied genetics</jtitle><stitle>Theor Appl Genet</stitle><addtitle>Theor Appl Genet</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>128</volume><issue>12</issue><spage>2471</spage><epage>2481</epage><pages>2471-2481</pages><issn>0040-5752</issn><eissn>1432-2242</eissn><abstract>Key message
Fusarium head blight and
Septoria tritici blotch resistances are complex traits and can be improved efficiently by genomic selection modeling main and epistatic effects.
Enhancing the resistance against Fusarium head blight (FHB) and Septoria tritici blotch (STB) is of central importance for a sustainable wheat production. Our study is based on a large experimental data set of 2325 inbred lines genotyped with 12,642 SNP markers and phenotyped in multi-environmental trials for FHB and STB resistance as well as for plant height. Our objectives were to (1) investigate the impact of plant height on FHB and STB severity, (2) examine the potential of marker-assisted selection, and (3) study the prediction ability of genomic selection modeling main and epistatic effects. We observed low correlations between plant height and FHB (
r
= −0.15;
P
< 0.05) as well as STB severity (
r
= −0.17;
P
< 0.05) suggesting negligible morphological resistances. Cross-validation in combination with association mapping revealed absence of large effect QTL impeding an efficient pyramiding of different resistance loci through marker-assisted selection. The prediction ability of genomic selection was high amounting to 0.6 for FHB and 0.5 for STB resistance. Therefore, genomic selection is a promising tool to improve FHB and STB resistance in wheat.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26350496</pmid><doi>10.1007/s00122-015-2602-1</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6098-1558</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0040-5752 |
| ispartof | Theoretical and applied genetics, 2015-12, Vol.128 (12), p.2471-2481 |
| issn | 0040-5752 1432-2242 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1746883850 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Agriculture Ascomycota Biochemistry Biomedical and Life Sciences Biotechnology Chromosome Mapping Disease Resistance - genetics Epistasis, Genetic Fungicides Fusarium Genomes Genotype Life Sciences Models, Genetic Original Article Pesticides Phenotype Plant Biochemistry Plant Breeding/Biotechnology Plant Diseases - genetics Plant Diseases - microbiology Plant Genetics and Genomics Polymorphism, Single Nucleotide Quantitative Trait Loci Selection, Genetic Septoria tritici Triticum - genetics Triticum - microbiology Triticum aestivum Wheat |
| title | Potential and limits of whole genome prediction of resistance to Fusarium head blight and Septoria tritici blotch in a vast Central European elite winter wheat population |
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