Using gene expression profiling to evaluate cellular responses in mouse lungs exposed to V2O5 and a group of other mouse lung tumorigens and non-tumorigens

Many compounds test positive for lung tumors in two-year NTP carcinogenicity bioassays in B6C3F1 mice. V2O5 was identified as a lung carcinogen in this assay, leading to its IARC (International Agency for Research on Cancer) classification as group 2b or a “possible” human carcinogen. To assess pote...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2015-10, Vol.73 (1), p.339-347
Hauptverfasser:	Black, Michael B., Dodd, Darol E., McMullen, Patrick D., Pendse, Salil, MacGregor, Judith A., Gollapudi, B. Bhaskar, Andersen, Melvin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Carcinogens - toxicity Cell Cycle - drug effects DNA Damage - drug effects Female Functional ontology Gene expression Gene Expression Profiling - methods Lung - drug effects Lung Neoplasms - chemically induced Mice Mice, Inbred Strains Microarray Analysis - methods Mouse lung Oxidative Stress - drug effects Transcriptome - drug effects Vanadium Compounds - toxicity Vanadium pentoxide
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