New investigations into the genotoxicity of cobalt compounds and their impact on overall assessment of genotoxic risk

The genotoxicity of cobalt metal and cobalt compounds has been widely studied. Several publications show induction of chromosomal aberrations, micronuclei or DNA damage in mammalian cells in vitro in the absence of S9. Mixed results were seen in gene mutation studies in bacteria and mammalian cells...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2015-10, Vol.73 (1), p.311-338
Hauptverfasser:	Kirkland, David, Brock, Tom, Haddouk, Hasnaà, Hargeaves, Victoria, Lloyd, Melvyn, Mc Garry, Sarah, Proudlock, Raymond, Sarlang, Séverine, Sewald, Katherina, Sire, Guillaume, Sokolowski, Andrea, Ziemann, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromosome Aberrations - chemically induced Cobalt - toxicity Cobalt compounds DNA Damage - drug effects Genotoxicity Humans Mutagenicity Tests - methods Mutagens - toxicity Mutation - drug effects Overall assessment
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