Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P‑Glycoprotein and α‑Glucosidase

Twelve new highly oxygenated lanostane triterpenoids and nine known ganoderic acids were isolated from the fruiting body of Ganoderma lucidum. The new compounds were lanostane nortriterpenoids with 27 carbons (1–5 and 8), lanostane nor-triterpenoids with 25 carbons (6 and 7), and lanostane triterpen...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2015-08, Vol.78 (8), p.1868-1876
Hauptverfasser:	Zhao, Xi-Run, Huo, Xiao-Kui, Dong, Pei-Pei, Wang, Chao, Huang, Shan-Shan, Zhang, Bao-Jing, Zhang, Hou-Li, Deng, Sa, Liu, Ke-Xin, Ma, Xiao-Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Glucosidases - drug effects ATP Binding Cassette Transporter, Sub-Family B - metabolism Doxorubicin - pharmacology Female Fruiting Bodies, Fungal - chemistry Ganoderma lucidum Glycoside Hydrolase Inhibitors - chemistry Glycoside Hydrolase Inhibitors - isolation & purification Glycoside Hydrolase Inhibitors - pharmacology Humans Lanosterol - chemistry Lanosterol - isolation & purification Lanosterol - pharmacology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Reishi - chemistry
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