The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death

Abundant evidence indicates that iron accumulation, oxidative damage and mitochondrial dysfunction are common features of Huntington's disease, Parkinson's disease, Friedreich's ataxia and a group of disorders known as Neurodegeneration with Brain Iron Accumulation. In this study, we...

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Veröffentlicht in:Biochemical and biophysical research communications 2015-08, Vol.463 (4), p.787-792
Hauptverfasser: Mena, Natalia P., García-Beltrán, Olimpo, Lourido, Fernanda, Urrutia, Pamela J., Mena, Raúl, Castro-Castillo, Vicente, Cassels, Bruce K., Núñez, Marco T.
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