d-Cycloserine acts via increasing the GluN1 protein expressions in the frontal cortex and decreases the avoidance and risk assessment behaviors in a rat traumatic stress model

•Three day d-cycloserine (DCS) served as an adjuvant to extinction therapy in predator scent test in rats.•GluN1 expressions were decreased in the amygdala and the dorsal hippocampus of rats with cat odor.•Extinction training together with DCS upregulated GluN1 in the affected brain regions of rats....

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Veröffentlicht in:	Behavioural brain research 2015-10, Vol.293, p.227-233
Hauptverfasser:	Sarıdoğan, Gökçe Elif, Aykaç, Aslı, Cabadak, Hülya, Cerit, Cem, Çalışkan, Mecit, Gören, M. Zafer
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdaloid complex Analysis of Variance Animals Antimetabolites - therapeutic use Avoidance Learning - drug effects Cats Cycloserine - therapeutic use Disease Models, Animal Dorsal hippocampus Extinction, Psychological - drug effects Female Freezing Reaction, Cataleptic - drug effects Frontal Lobe - drug effects Frontal Lobe - metabolism Gene Expression Regulation - drug effects Male Odorants Post-traumatic stress disorder Predator scent test Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - metabolism Reflex, Stretch - drug effects Risk Assessment Stress Disorders, Traumatic - drug therapy Stress Disorders, Traumatic - pathology Stress Disorders, Traumatic - physiopathology
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