Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer’s disease

•Intranasal administration of SHED-CM improves cognition in a mouse model of AD.•SHED-CM converts the pro-inflammatory AD environment to an anti-inflammatory one.•SHED-CM induces the accumulation of M2 microglia in the mouse AD brain.•SHEDs secrete multiple factors beneficial for the treatment of AD...

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Veröffentlicht in:	Behavioural brain research 2015-10, Vol.293, p.189-197
Hauptverfasser:	Mita, Tsuneyuki, Furukawa-Hibi, Yoko, Takeuchi, Hideyuki, Hattori, Hisashi, Yamada, Kiyofumi, Hibi, Hideharu, Ueda, Minoru, Yamamoto, Akihito
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Alzheimer Disease - chemically induced Alzheimer Disease - complications Alzheimer’s disease Amyloid beta-Peptides - toxicity Animals Cell Survival - drug effects Cells, Cultured Cerebral Cortex - cytology Cognition Disorders - therapy Culture Media, Conditioned - chemistry Culture Media, Conditioned - pharmacology Cytokines - genetics Cytokines - metabolism Dental Pulp - cytology Dental pulp stem cells Disease Models, Animal Embryo, Mammalian Glutamic Acid - toxicity Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Intranasal administration Male Mice Mice, Inbred C57BL Mice, Inbred ICR Microglia Neurons - drug effects Peptide Fragments - toxicity Recognition (Psychology) - drug effects Stem cell-conditioned medium Stem Cells - chemistry
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