Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats

•One week administration of IFN-α induces depression-like behaviour in the rat forced swim test.•IFN-α treatment alters brain tryptophan levels and downstream kynurenine metabolites.•Imipramine reverses IFN-α-induced depression-like behaviour.•Celecoxib shows potential for antidepressant activity po...

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Veröffentlicht in:	Behavioural brain research 2015-10, Vol.293, p.166-172
Hauptverfasser:	Fischer, Christina Weide, Eskelund, Amanda, Budac, David P., Tillmann, Sandra, Liebenberg, Nico, Elfving, Betina, Wegener, Gregers
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antidepressive Agents - therapeutic use Chromatography, Liquid Depression Depression - chemically induced Depression - drug therapy Depression - pathology Dose-Response Relationship, Drug Electrochemistry Food Preferences - drug effects Hippocampus - drug effects Hippocampus - metabolism Illness Behavior - drug effects Interferon-alpha Interferon-alpha - toxicity Male Quinolinic Acid - metabolism Rats Rats, Sprague-Dawley Saccharin - administration & dosage Statistics, Nonparametric Sweetening Agents - administration & dosage Swimming - psychology Tryptophan - metabolism Tryptophan–kynurenine pathway
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