Lithium chloride administration prevents spatial learning and memory impairment in repeated cerebral ischemia-reperfusion mice by depressing apoptosis and increasing BDNF expression in hippocampus

•Repeated cerebral ischemia-reperfusion (IR) dynamically increased Bcl-2/Bax and BDNF.•Pre-LiCl and LiCl induced a pronounced prevention on cognitive impairment in Morris water maze.•2mmol/kg LiCl reversed the morphologic changes and up-regulated the survival neuron count.•2mmol/kg LiCl increased th...

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Veröffentlicht in:	Behavioural brain research 2015-09, Vol.291, p.399-406
Hauptverfasser:	Fan, Mingyue, Jin, Wei, Zhao, Haifeng, Xiao, Yining, Jia, Yanqiu, Yin, Yu, Jiang, Xin, Xu, Jing, Meng, Nan, Lv, Peiyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology Bax Bcl-2 bcl-2-Associated X Protein - metabolism BDNF Brain Ischemia - drug therapy Brain Ischemia - physiopathology Brain-Derived Neurotrophic Factor - metabolism Carotid Artery Diseases Cell Survival - drug effects Cell Survival - physiology Cyclic AMP Response Element-Binding Protein - metabolism Disease Models, Animal Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology Learning Learning Disorders - pathology Learning Disorders - physiopathology Learning Disorders - prevention & control Lithium chloride Lithium Chloride - pharmacology Male Maze Learning - drug effects Maze Learning - physiology Memory Memory Disorders - pathology Memory Disorders - physiopathology Memory Disorders - prevention & control Mice, Inbred C57BL Neurons - drug effects Neurons - pathology Neurons - physiology Nootropic Agents - pharmacology p-CREB Proto-Oncogene Proteins c-bcl-2 - metabolism Random Allocation Repeated cerebral ischemia-reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - physiopathology Spatial Memory - drug effects Spatial Memory - physiology
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