Extracellular methemoglobin primes red blood cell aggregation in malaria: An in vitro mechanistic study

► Methemoglobin exposure causes RBC aggregation. ► The high order aggregates are irreversible and resistant to physical disaggregation. ► Oxidative insult to RBC causes PS externalization to initiate and form aggregates. ► Antioxidant treatment especially inhibits high order RBC aggregate formation....

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Veröffentlicht in:	FEBS letters 2013-02, Vol.587 (4), p.350-357
Hauptverfasser:	Balaji, S.N., Trivedi, Vishal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aggregation Anemia - etiology Anemia - prevention & control Antioxidants - pharmacology Antioxidants - therapeutic use Biological Transport - drug effects Culture Media, Conditioned - metabolism Cytoadherence Erythrocyte Aggregation - drug effects Erythrocytes - drug effects Erythrocytes - metabolism Erythrocytes - parasitology Female Humans Malaria, Falciparum - drug therapy Malaria, Falciparum - metabolism Malaria, Falciparum - parasitology Malaria, Falciparum - physiopathology Male Methemoglobin Methemoglobin - metabolism Methemoglobin - secretion Molecular Targeted Therapy Oxidative Stress - drug effects Phosphatidylserines - metabolism Plasmodium falciparum - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Red blood cell Surface Properties - drug effects Vascular Diseases - etiology Vascular Diseases - prevention & control Vesicular blockage Young Adult
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