Protective effect of Fenofibrate in renal ischemia reperfusion injury: Involved in suppressing kinase 2 (JAK2)/transcription 3 (STAT3)/p53 signaling activation

Renal ischemia reperfusion (I/R) injury is a common reason of acute kidney injury. Apoptosis play an important role in the IRI. Fenofibrate, one of agonist Peroxisome proliferator-activated receptor-alpha (PPARα) has the effect of anti-apoptosis. This study was to explore the effect of Fenofibrate o...

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Veröffentlicht in:	Pathologie biologie (Paris) 2015-12, Vol.63 (6), p.236-242
Hauptverfasser:	Lv, J., Wang, X., Liu, S.Y., Liang, P.F., Feng, M., Zhang, L.L., Xu, A.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptose Apoptosis Cytoprotection - drug effects Fenofibrate Fenofibrate - pharmacology Fénofibrate Ischemia/reperfusion injury JAK2/STAT3/p53 Janus Kinase 2 - metabolism Kidney - blood supply Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - metabolism Kidney Diseases - prevention & control Kidney Function Tests Lésions d’ischémie-reperfusion Male Mice Mice, Inbred C57BL Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Tumor Suppressor Protein p53 - metabolism
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