Cellular Composition of the Spleen and Changes in Splenic Lysosomes in the Dynamics of Dyslipidemia in Mice Caused by Repeated Administration of Poloxamer 407

We studied the effect of dyslipidemia induced by poloxamer 407 (300 mg/kg twice a week for 30 days) on cellular composition of the spleen and splenocyte lysosomes in mice. Changes in blood lipid profile included elevated concentrations of total cholesterol, aterogenic LDL, and triglycerides most pro...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2015-11, Vol.160 (1), p.28-31
Hauptverfasser:	Goncharova, N. V., Shurlygina, A. V., Mel’nikova, E. V., Karmatskikh, O. L., Avrorov, P. A., Loktev, K. V., Korolenko, T. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomedical and Life Sciences Biomedicine Cathepsin D - analysis Cathepsins Cell Biology Cholesterol Cholesterol - blood Cholesterol, LDL - blood Dyslipidemias - blood Dyslipidemias - chemically induced Dyslipidemias - pathology Internal Medicine Laboratory Medicine Low density lipoproteins Lysosomes - drug effects Lysosomes - ultrastructure Male Mice Mice, Inbred CBA Organ Size - drug effects Pathology Poloxamer - toxicity Spleen - drug effects Spleen - enzymology Spleen - pathology Spleen - ultrastructure Triglycerides Triglycerides - blood
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