Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection
BACKGROUND: The outcome of surgically resected, apparently localized, clear cell renal carcinoma (ccRCC) is uncertain. OBJECTIVE: To evaluate if cell cycle progression (CCP) gene expression can predict future metastasis. METHODS: Pathologic T2a-T3b tumors at University of Iowa were reviewed. Patient...
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| Veröffentlicht in: | Cancer biomarkers : section A of Disease markers 2015-01, Vol.15 (6), p.861-867 |
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| container_title | Cancer biomarkers : section A of Disease markers |
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| creator | Askeland, Eric J. Chehval, Vincent A. Askeland, Ryan W. Fosso, Placede G. Sangale, Zaina Xu, Nafei Rajamani, Saradha Stone, Steven Brown, James A. |
| description | BACKGROUND: The outcome of surgically resected, apparently localized, clear cell renal carcinoma (ccRCC) is uncertain.
OBJECTIVE: To evaluate if cell cycle progression (CCP) gene expression can predict future metastasis.
METHODS: Pathologic T2a-T3b tumors at University of Iowa were reviewed. Patients with known or suspected metastasis, lymph node involvement or who received neoadjuvant or adjuvant radiation, chemotherapy or immunotherapy were excluded. Case and control cohorts were defined as those who did or did not develop metastatic disease within 5 years. Measured levels of 31 cell cycle genes and 15 control genes from the tumor were calculated as a CCP score. Additionally, gene expression data for a separate ccRCC cohort was downloaded from The Cancer Genome Atlas (TCGA).
RESULTS: Univariate analysis of 26 cases and 38 controls revealed that the CCP score predicted progression to metastasis (OR 2.65, p = 0.0091). In multivariate logistic regression modeling, CCP expression remained a significant independent predictor for progression (p = 0.026). The CCP score was also significantly associated with distant metastasis in the TCGA renal cancer cohort in both univariate (p = 1.0 × 10-9) and multivariate (p = 5.6 × 10-3) analysis.
CONCLUSION: The CCP score has prognostic value in predicting metastatic progression after resection of organ-confined ccRCC. |
| doi_str_mv | 10.3233/CBM-150530 |
| format | Article |
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OBJECTIVE: To evaluate if cell cycle progression (CCP) gene expression can predict future metastasis.
METHODS: Pathologic T2a-T3b tumors at University of Iowa were reviewed. Patients with known or suspected metastasis, lymph node involvement or who received neoadjuvant or adjuvant radiation, chemotherapy or immunotherapy were excluded. Case and control cohorts were defined as those who did or did not develop metastatic disease within 5 years. Measured levels of 31 cell cycle genes and 15 control genes from the tumor were calculated as a CCP score. Additionally, gene expression data for a separate ccRCC cohort was downloaded from The Cancer Genome Atlas (TCGA).
RESULTS: Univariate analysis of 26 cases and 38 controls revealed that the CCP score predicted progression to metastasis (OR 2.65, p = 0.0091). In multivariate logistic regression modeling, CCP expression remained a significant independent predictor for progression (p = 0.026). The CCP score was also significantly associated with distant metastasis in the TCGA renal cancer cohort in both univariate (p = 1.0 × 10-9) and multivariate (p = 5.6 × 10-3) analysis.
CONCLUSION: The CCP score has prognostic value in predicting metastatic progression after resection of organ-confined ccRCC.</description><identifier>ISSN: 1574-0153</identifier><identifier>EISSN: 1875-8592</identifier><identifier>DOI: 10.3233/CBM-150530</identifier><identifier>PMID: 26406412</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Biomarkers, Tumor - genetics ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - secondary ; Carcinoma, Renal Cell - surgery ; Case-Control Studies ; Cell Cycle - genetics ; Cell Cycle Proteins - genetics ; Female ; Follow-Up Studies ; Humans ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; Real-Time Polymerase Chain Reaction ; Retrospective Studies</subject><ispartof>Cancer biomarkers : section A of Disease markers, 2015-01, Vol.15 (6), p.861-867</ispartof><rights>IOS Press and the authors. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-181bf0bfde7d8f9969969b96d80a99807d363d335b7a9f5bdb2442a350030c953</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.3233/CBM-150530$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.3233/CBM-150530$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,21946,27832,27903,27904,44924,45312</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26406412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Askeland, Eric J.</creatorcontrib><creatorcontrib>Chehval, Vincent A.</creatorcontrib><creatorcontrib>Askeland, Ryan W.</creatorcontrib><creatorcontrib>Fosso, Placede G.</creatorcontrib><creatorcontrib>Sangale, Zaina</creatorcontrib><creatorcontrib>Xu, Nafei</creatorcontrib><creatorcontrib>Rajamani, Saradha</creatorcontrib><creatorcontrib>Stone, Steven</creatorcontrib><creatorcontrib>Brown, James A.</creatorcontrib><title>Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection</title><title>Cancer biomarkers : section A of Disease markers</title><addtitle>Cancer Biomark</addtitle><description>BACKGROUND: The outcome of surgically resected, apparently localized, clear cell renal carcinoma (ccRCC) is uncertain.
OBJECTIVE: To evaluate if cell cycle progression (CCP) gene expression can predict future metastasis.
METHODS: Pathologic T2a-T3b tumors at University of Iowa were reviewed. Patients with known or suspected metastasis, lymph node involvement or who received neoadjuvant or adjuvant radiation, chemotherapy or immunotherapy were excluded. Case and control cohorts were defined as those who did or did not develop metastatic disease within 5 years. Measured levels of 31 cell cycle genes and 15 control genes from the tumor were calculated as a CCP score. Additionally, gene expression data for a separate ccRCC cohort was downloaded from The Cancer Genome Atlas (TCGA).
RESULTS: Univariate analysis of 26 cases and 38 controls revealed that the CCP score predicted progression to metastasis (OR 2.65, p = 0.0091). In multivariate logistic regression modeling, CCP expression remained a significant independent predictor for progression (p = 0.026). The CCP score was also significantly associated with distant metastasis in the TCGA renal cancer cohort in both univariate (p = 1.0 × 10-9) and multivariate (p = 5.6 × 10-3) analysis.
CONCLUSION: The CCP score has prognostic value in predicting metastatic progression after resection of organ-confined ccRCC.</description><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - secondary</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Case-Control Studies</subject><subject>Cell Cycle - genetics</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Retrospective Studies</subject><issn>1574-0153</issn><issn>1875-8592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNptkE1LxDAQhoMo7rp68QdIb4pQTZqmbY5a_IIVL3oOaT6WLm2zZtLD_ntTqoIghGSYPPMyPAidE3xDM0pv6_vXlDDMKD5AS1KVLK0Yzw5jzco8xYTRBToB2GKcU5LxY7TIihwXOcmWyNWm6xK1V51Jdt5tvAFo3ZCAcn7qGN2qAElvgoQgQ6v-UM4mcVD6RE0p3gyym0slvWoH18tE2mB8_AKjQhw5RUdWdmDOvt8V-nh8eK-f0_Xb00t9t04V5UVISUUaixurTakry3kxnYYXusKS8wqXmhZUU8qaUnLLGt1keZ5JyjCmWHFGV-hqzo3rfo4GguhbmFaTg3EjCFLmRVXGO4_o9Ywq7wC8sWLn2176vSBYTIJFFCxmwRG--M4dm97oX_THaAQuZwDkxoitG32UAv9FfQFTUoLi</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Askeland, Eric J.</creator><creator>Chehval, Vincent A.</creator><creator>Askeland, Ryan W.</creator><creator>Fosso, Placede G.</creator><creator>Sangale, Zaina</creator><creator>Xu, Nafei</creator><creator>Rajamani, Saradha</creator><creator>Stone, Steven</creator><creator>Brown, James A.</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection</title><author>Askeland, Eric J. ; Chehval, Vincent A. ; Askeland, Ryan W. ; Fosso, Placede G. ; Sangale, Zaina ; Xu, Nafei ; Rajamani, Saradha ; Stone, Steven ; Brown, James A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-181bf0bfde7d8f9969969b96d80a99807d363d335b7a9f5bdb2442a350030c953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma, Renal Cell - genetics</topic><topic>Carcinoma, Renal Cell - secondary</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>Case-Control Studies</topic><topic>Cell Cycle - genetics</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Askeland, Eric J.</creatorcontrib><creatorcontrib>Chehval, Vincent A.</creatorcontrib><creatorcontrib>Askeland, Ryan W.</creatorcontrib><creatorcontrib>Fosso, Placede G.</creatorcontrib><creatorcontrib>Sangale, Zaina</creatorcontrib><creatorcontrib>Xu, Nafei</creatorcontrib><creatorcontrib>Rajamani, Saradha</creatorcontrib><creatorcontrib>Stone, Steven</creatorcontrib><creatorcontrib>Brown, James A.</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer biomarkers : section A of Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Askeland, Eric J.</au><au>Chehval, Vincent A.</au><au>Askeland, Ryan W.</au><au>Fosso, Placede G.</au><au>Sangale, Zaina</au><au>Xu, Nafei</au><au>Rajamani, Saradha</au><au>Stone, Steven</au><au>Brown, James A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection</atitle><jtitle>Cancer biomarkers : section A of Disease markers</jtitle><addtitle>Cancer Biomark</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>15</volume><issue>6</issue><spage>861</spage><epage>867</epage><pages>861-867</pages><issn>1574-0153</issn><eissn>1875-8592</eissn><abstract>BACKGROUND: The outcome of surgically resected, apparently localized, clear cell renal carcinoma (ccRCC) is uncertain.
OBJECTIVE: To evaluate if cell cycle progression (CCP) gene expression can predict future metastasis.
METHODS: Pathologic T2a-T3b tumors at University of Iowa were reviewed. Patients with known or suspected metastasis, lymph node involvement or who received neoadjuvant or adjuvant radiation, chemotherapy or immunotherapy were excluded. Case and control cohorts were defined as those who did or did not develop metastatic disease within 5 years. Measured levels of 31 cell cycle genes and 15 control genes from the tumor were calculated as a CCP score. Additionally, gene expression data for a separate ccRCC cohort was downloaded from The Cancer Genome Atlas (TCGA).
RESULTS: Univariate analysis of 26 cases and 38 controls revealed that the CCP score predicted progression to metastasis (OR 2.65, p = 0.0091). In multivariate logistic regression modeling, CCP expression remained a significant independent predictor for progression (p = 0.026). The CCP score was also significantly associated with distant metastasis in the TCGA renal cancer cohort in both univariate (p = 1.0 × 10-9) and multivariate (p = 5.6 × 10-3) analysis.
CONCLUSION: The CCP score has prognostic value in predicting metastatic progression after resection of organ-confined ccRCC.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26406412</pmid><doi>10.3233/CBM-150530</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers, Tumor - genetics Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - secondary Carcinoma, Renal Cell - surgery Case-Control Studies Cell Cycle - genetics Cell Cycle Proteins - genetics Female Follow-Up Studies Humans Kidney Neoplasms - genetics Kidney Neoplasms - pathology Kidney Neoplasms - surgery Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Prognosis Real-Time Polymerase Chain Reaction Retrospective Studies |
| title | Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection |
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