Retrotransposition and Crystal Structure of an Alu RNP in the Ribosome-Stalling Conformation

The Alu element is the most successful human genomic parasite affecting development and causing disease. It originated as a retrotransposon during early primate evolution of the gene encoding the signal recognition particle (SRP) RNA. We defined a minimal Alu RNA sufficient for effective retrotransp...

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Veröffentlicht in:	Molecular cell 2015-12, Vol.60 (5), p.715-727
Hauptverfasser:	Ahl, Valentina, Keller, Heiko, Schmidt, Steffen, Weichenrieder, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Alu Elements Animals Binding Sites Crystallography, X-Ray HeLa Cells Humans LINE mobile DNA Models, Molecular molecular evolution Nucleic Acid Conformation Protein Structure, Tertiary Ribosomes - metabolism RNA - chemistry RNA - metabolism RNA structure Signal Recognition Particle - chemistry Signal Recognition Particle - metabolism SINE translational control
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