Molecular Dynamics Simulation Links Conformation of a Pore-Flanking Region to Hyperekplexia-Related Dysfunction of the Inhibitory Glycine Receptor

Inhibitory glycine receptors mediate rapid synaptic inhibition in mammalian spinal cord and brainstem. The previously identified hyperekplexia mutation GLRA1(P250T), located within the intracellular TM1-2 loop of the GlyR α1 subunit, results in altered receptor activation and desensitization. Here,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemistry & biology 2004-10, Vol.11 (10), p.1339-1350
Hauptverfasser:	Breitinger, Hans-Georg, Lanig, Harald, Vohwinkel, Christine, Grewer, Christof, Breitinger, Ulrike, Clark, Tim, Becker, Cord-Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Computer Simulation Dose-Response Relationship, Drug Glycine - metabolism Glycine - pharmacology Helix-Turn-Helix Motifs - genetics Humans Ion Channels - antagonists & inhibitors Ion Channels - genetics Models, Molecular Mutagenesis, Site-Directed Myoclonus - genetics Myoclonus - physiopathology Neural Inhibition - genetics Patch-Clamp Techniques Protein Conformation Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - physiology Receptors, Glycine - chemistry Receptors, Glycine - genetics Receptors, Glycine - physiology Reflex, Startle - genetics Stiff-Person Syndrome - genetics Stiff-Person Syndrome - physiopathology Thermodynamics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!