Rational Design of Sequence-Specific DNA Alkylating Agents Based on Duocarmycin A and Pyrrole−Imidazole Hairpin Polyamides

Synthesis of novel conjugates between segment A of Duocarmycin A (Du) and N-methylimidazole (Im)−N-methylpyrrole (Py) hairpin polyamides and their DNA alkylation are described. The conjugates PyPyPyγImPyPyDu (8a) and ImPyPyγImPyPyDu (8b) were designed to alkylate the target sequences (A/T)G(A/T)2N(A...

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Veröffentlicht in:	Journal of the American Chemical Society 1999-06, Vol.121 (21), p.4961-4967
Hauptverfasser:	Tao, Zhi-Fu, Fujiwara, Tsuyoshi, Saito, Isao, Sugiyama, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA alkylation Duocarmycin A duocarmycin SA N-methylimidazole-N-methylpyrrole oligonucleotides polyamides
Online-Zugang:	Volltext
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