Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70

Geranylgeranylacetone (GGA), an anti-ulcer drug, has been reported to induce heat shock protein (HSP) 70 in several animal organs. The present study was performed to determine whether GGA protects mouse liver against acetaminophen (APAP)-induced injury and whether it has potential as a therapeutic a...

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Veröffentlicht in:	Toxicology (Amsterdam) 2006-02, Vol.219 (1), p.187-196
Hauptverfasser:	Nishida, Tadashi, Matsura, Tatsuya, Nakada, Junya, Togawa, Aki, Kai, Masachika, Sumioka, Isao, Minami, Yukari, Inagaki, Yoshimi, Ishibe, Yuichi, Ito, Hisao, Ohta, Yoshiji, Yamada, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - antagonists & inhibitors Acetaminophen - toxicity Alanine Transaminase - metabolism Ammonia - blood Analgesics, Non-Narcotic - antagonists & inhibitors Analgesics, Non-Narcotic - toxicity Animals Anti-Ulcer Agents - pharmacology Aspartate Aminotransferases - metabolism Biological and medical sciences Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Cytochrome P-450 CYP2E1 - biosynthesis Diterpenes - pharmacology Geranylgeranylacetone Glutathione - metabolism Heat shock protein Hepatotoxicity HSP70 Heat-Shock Proteins - biosynthesis In Vitro Techniques Lipid Peroxidation - drug effects Liver - pathology Male Medical sciences Mice Microsomes, Liver - drug effects Microsomes, Liver - enzymology Mouse Necrosis Peroxidase - metabolism Toxicology
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