Pharmacokinetic Factors and Concentration-Time Threshold in m-Dinitrobenzene-Induced Neurotoxicity

m-Dinitrobenzene is a multitarget toxicant. This study presents a concentration-time threshold model in m-dinitrobenzene (m-DNB)-induced neurotoxicity in F344 rats based on pharmacokinetic modeling and variable duration infusions with neuropathological end points. Pharmacokinetic parameters for m-DN...

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Veröffentlicht in:	Toxicology and applied pharmacology 1999-12, Vol.161 (3), p.267-273
Hauptverfasser:	Xu, Jinsheng, Nolan, Chris C., Lister, Timothy, Purcell, Wendy M., Ray, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-nitroaniline Aniline Compounds - pharmacokinetics Aniline Compounds - toxicity Animals Biological and medical sciences Brain - drug effects Brain - metabolism Brain - pathology brain damage Chemical and industrial products toxicology. Toxic occupational diseases Chromatography, High Pressure Liquid dinitrobenzene Dinitrobenzenes - administration & dosage Dinitrobenzenes - pharmacokinetics Dinitrobenzenes - toxicity Dose-Response Relationship, Drug Female half-life infusion Infusions, Intravenous Injections, Intravenous liver m-Dinitrobenzene m-dinitrobenzene (m-DNB) Medical sciences metabolism Models, Biological Nervous System Diseases - chemically induced Nervous System Diseases - metabolism neurotoxicity pharmacokinetics rat Rats Rats, Inbred F344 spinal cord testis threshold time Time Factors Tissue Distribution Toxicology Various organic compounds
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