Expression of H5 hemagglutinin vaccine antigen in common duckweed ( Lemna minor ) protects against H5N1 high pathogenicity avian influenza virus challenge in immunized chickens

Abstract A synthetic hemagglutinin (HA) gene from the highly pathogenic avian influenza (HPAI) virus A/chicken/Indonesia/7/2003 (H5N1) (Indo/03) was expressed in aquatic plant Lemna minor (r Lemna -HA). In Experiment 1, efficacy of r Lemna -HA was tested on birds immunized with 0.2 μg or 2.3 μg HA a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-07, Vol.33 (30), p.3456-3462
Hauptverfasser:	Bertran, Kateri, Thomas, Colleen, Guo, Xuan, Bublot, Michel, Pritchard, Nikki, Regan, Jeffrey T, Cox, Kevin M, Gasdaska, John R, Dickey, Lynn F, Kapczynski, Darrell R, Swayne, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals antibodies Antigens Aquatic plants Araceae - genetics Araceae - metabolism avian influenza Avian influenza virus Birds Cellulose acetate Chickens dosage Embryos Experiments Floating plants Gene Expression H5N1 high pathogenicity avian influenza Hemagglutinin Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - metabolism hemagglutinins humoral immunity Immunization Influenza A virus Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - immunology Influenza in Birds - prevention & control Influenza Vaccines - administration & dosage Influenza Vaccines - genetics Influenza Vaccines - immunology Laboratory animals Lemna minor Molecular weight Mortality pathogenicity Pathogens Plant-derived vaccine Plants, Genetically Modified - genetics Plants, Genetically Modified - metabolism Poultry Proteins Seeds strains Survival Analysis survival rate synthetic genes transgenic plants Treatment Outcome Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology viral shedding Virus Shedding Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!