Bisphosphonate-Mediated Gene Vector Delivery from the Metal Surfaces of Stents

The clinical use of metallic expandable intravascular stents has resulted in improved therapeutic outcomes for coronary artery disease. However, arterial reobstruction after stenting, in-stent restenosis, remains an important problem. Gene therapy to treat in-stent restenosis by using gene vector de...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-01, Vol.103 (1), p.159-164
Hauptverfasser:	Fishbein, Ilia, Alferiev, Ivan S., Nyanguile, Origene, Gaster, Richard, Vohs, John M., Wong, Gordon S., Felderman, Howard, Chen, I-Wei, Choi, Hoon, Wilensky, Robert L., Levy, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - metabolism Alloys Angioplasty Angioplasty - methods Animals Antibodies Arteries Biological Sciences Blood vessels Cardiovascular disease Cells, Cultured Coronary Artery Disease - complications Coronary Artery Disease - surgery Diphosphonates Diphosphonates - metabolism Gene therapy Genes, Reporter - genetics Genetic Therapy - methods Genetic vectors Genetic Vectors - metabolism Genetic Vectors - therapeutic use Graft Occlusion, Vascular - etiology Graft Occlusion, Vascular - therapy Green Fluorescent Proteins - metabolism Male Medical treatment Metal surfaces Metals Nitric Oxide Synthase Type II - metabolism Polyamines - metabolism Rats Rats, Sprague-Dawley Spectrum Analysis Steels Stents Transduction, Genetic - methods
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