Cross-species Vascular Endothelial Growth Factor (VEGF)-blocking Antibodies Completely Inhibit the Growth of Human Tumor Xenografts and Measure the Contribution of Stromal VEGF

To fully assess the role of VEGF-A in tumor angiogenesis, antibodies that can block all sources of vascular endothelial growth factor (VEGF) are desired. Selectively targeting tumor-derived VEGF overlooks the contribution of host stromal VEGF. Other strategies, such as targeting VEGF receptors direc...

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Veröffentlicht in:	The Journal of biological chemistry 2006-01, Vol.281 (2), p.951-961
Hauptverfasser:	Liang, Wei-Ching, Wu, Xiumin, Peale, Franklin V., Lee, Chingwei V., Meng, Y. Gloria, Gutierrez, Johnny, Fu, Ling, Malik, Ajay K., Gerber, Hans-Peter, Ferrara, Napoleone, Fuh, Germaine
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal, Humanized Bevacizumab Cell Line, Tumor Cells, Cultured Disease Models, Animal Disease Progression Dose-Response Relationship, Drug Endothelium, Vascular - cytology Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin G - chemistry Kinetics Mice Mice, Nude Molecular Sequence Data Muscle, Skeletal - metabolism Neoplasm Transplantation Neovascularization, Pathologic Peptide Library Protein Binding Species Specificity Umbilical Veins - cytology Vascular Endothelial Growth Factor A - chemistry Vascular Endothelial Growth Factor A - immunology Vascular Endothelial Growth Factor A - metabolism
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