Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model

Resiniferatoxin is a potent capsaicin analog. Intrathecal administration leads to selective, prolonged opening of the transient receptor potential V1 ion channel, which is localized mainly to C-fiber primary afferent nociceptive sensory neurons. Following work in laboratory animals, the authors expl...

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