The T-superfamily of Conotoxins

We report the discovery and initial characterization of the T-superfamily of conotoxins. Eight different T-superfamily peptides from five Conusspecies were identified; they share a consensus signal sequence, and a conserved arrangement of cysteine residues (- -CC- -CC-). T-superfamily peptides were...

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Veröffentlicht in:	The Journal of biological chemistry 1999-10, Vol.274 (43), p.30664-30671
Hauptverfasser:	Walker, Craig S., Steel, Douglas, Jacobsen, Richard B., Lirazan, Marcelina B., Cruz, Lourdes J., Hooper, David, Shetty, Reshma, DelaCruz, Richard C., Nielsen, Jacob S., Zhou, Li Ming, Bandyopadhyay, Pradip, Craig, A. Grey, Olivera, Baldomero M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Cloning, Molecular conotoxin conotoxins Conotoxins - chemistry Conotoxins - genetics Conotoxins - toxicity Consensus Sequence Conus Cysteine Fishes Mice Molecular Sequence Data Motor Activity - drug effects Protein Processing, Post-Translational Protein Sorting Signals - chemistry Recombinant Proteins - chemistry Sequence Alignment Sequence Homology, Amino Acid Snails - genetics
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