Recognition of 16 Base Pairs in the Minor Groove of DNA by a Pyrrole−Imidazole Polyamide Dimer

Cell-permeable small molecules that bind predetermined DNA sequences with affinities and specificities comparable to those of natural DNA-binding proteins have the potential to regulate the expression of specific genes. Recently, an eight-ring hairpin pyrrole-imidazole (Py-Im) polyamide which binds...

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Veröffentlicht in:	Journal of the American Chemical Society 1998-04, Vol.120 (14), p.3534-3535
Hauptverfasser:	Trauger, John W, Baird, Eldon E, Dervan, Peter B
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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