Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents

The syntheses and exceptional antitumor activities of a series of novel fatty acid-second-generation taxoid conjugates against human tumor xenografts are reported. Polyunsaturated fatty acids such as docosahexaenoic acid (DHA), linolenic acid, and linoleic acid were linked to the C-2′ position of th...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-02, Vol.16 (4), p.974-977
Hauptverfasser:	Kuznetsova, Larissa, Chen, Jin, Sun, Liang, Wu, Xinyuan, Pepe, Antonella, Veith, Jean M., Pera, Paula, Bernacki, Ralph J., Ojima, Iwao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer agent Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Cancer Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Conjugate Drug Screening Assays, Antitumor Fatty acid Fatty Acids, Unsaturated - chemistry General aspects Humans Medical sciences Molecular Conformation Pharmacology. Drug treatments Structure-Activity Relationship Taxane Taxoid Taxoids - chemical synthesis Taxoids - chemistry Taxoids - pharmacology Tumor targeting
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