Role of Cytochrome c as a Stimulator of α-Synuclein Aggregation in Lewy Body Disease

α-Synuclein is a major component of aggregates forming amyloid-like fibrils in diseases with Lewy bodies and other neurodegenerative disorders, yet the mechanism by which α-synuclein is intracellularly aggregated during neurodegeneration is poorly understood. Recent studies suggest that oxidative st...

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Veröffentlicht in:	The Journal of biological chemistry 1999-10, Vol.274 (41), p.28849-28852
Hauptverfasser:	Hashimoto, Makoto, Takeda, Ayako, Hsu, Leigh J., Takenouchi, Takato, Masliah, Eliezer
Format:	Artikel
Sprache:	eng
Schlagworte:	a-Synuclein Acetylcysteine - pharmacology alpha-Synuclein Antioxidants - pharmacology Brain - pathology Brain - ultrastructure Cytochrome c Cytochrome c Group - analysis Cytochrome c Group - metabolism Deferoxamine - pharmacology hemin Humans Hydrogen Peroxide - pharmacology Immunohistochemistry Lewy Body Disease - metabolism Lewy Body Disease - pathology Nerve Tissue Proteins - analysis Nerve Tissue Proteins - metabolism Oxidative Stress Recombinant Proteins - metabolism Synucleins
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