The steroid hormone dehydroepiandrosterone inhibits CYP1A1 expression in vitro by a post-transcriptional mechanism

The adrenal steroid hormone dehydroepiandrosterone (DHEA) is a potent inhibitor of mammary carcinogenesis induced by polycyclic aromatic hydrocarbons (PAH), though its mechanism is unclear. We examined the effect of DHEA on the expression of the carcinogen-activating enzyme cytochrome P450 1A1 (CYP1...

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Veröffentlicht in:	The Journal of biological chemistry 1999-12, Vol.274 (49), p.35186-35190
Hauptverfasser:	Ciolino, H P, Yeh, G C
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,7,8-tetrachlorodibenzo-p-dioxin 9,10-Dimethyl-1,2-benzanthracene - pharmacology Actinomycin D Carcinogens - pharmacology CYP1A1 gene Cytochrome P-450 CYP1A1 - antagonists & inhibitors Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Dehydroepiandrosterone Dehydroepiandrosterone - pharmacology Dehydroepiandrosterone Sulfate - pharmacology Dose-Response Relationship, Drug Humans Neoplasms - prevention & control Polychlorinated Dibenzodioxins - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA Processing, Post-Transcriptional - drug effects RNA, Messenger - drug effects RNA, Messenger - metabolism Time Factors Transfection Tumor Cells, Cultured
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