A conserved seven amino acid stretch important for murine mitochondrial glycerol-3-phosphate acyltransferase activity. Significance of arginine 318 in catalysis

Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and committed step in glycerolipid biosynthesis. We previously cloned the cDNA sequence to murine mitochondrial GPAT (Yet, S-F., Lee, S., Hahm, Y. T., and Sul, H.S. (1993) Biochemistry 32, 9486-9491). We expressed the protein in insec...

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Veröffentlicht in:	The Journal of biological chemistry 1999-12, Vol.274 (49), p.34728-34734
Hauptverfasser:	Dircks, L K, Ke, J, Sul, H S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - metabolism Animals Base Sequence Blotting, Northern Blotting, Western Catalysis Conserved Sequence COS Cells cyclohexanedione Cyclohexanones - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology glycerol-3-phosphate acyltransferase Glycerol-3-Phosphate O-Acyltransferase - antagonists & inhibitors Glycerol-3-Phosphate O-Acyltransferase - chemistry Glycerol-3-Phosphate O-Acyltransferase - genetics Glycerol-3-Phosphate O-Acyltransferase - metabolism glycerolipids Kinetics Mice Mitochondria - enzymology Molecular Sequence Data phenylglyoxal Phenylglyoxal - pharmacology Plasmids - metabolism Sequence Homology, Amino Acid Substrate Specificity Transfection Trypsin - pharmacology
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