Antinociceptive effects of metamizol (dipyrone) in rat single motor units

Metamizol has been considered as a peripherally acting non-steroidal antiinflammatory drug, though a central action is possible. The aim of the present study was to elucidate if metamizol induces antinociception in the single motor unit preparation, in normal rats versus rats with carrageenan-induce...

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Veröffentlicht in:	Neuroscience letters 1999-10, Vol.274 (3), p.179-182
Hauptverfasser:	Mazario, Javier, Herrero, Juan F
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Arthritis - chemically induced Arthritis - physiopathology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Carrageenan Dipyrone - pharmacology Dose-Response Relationship, Drug Electric Stimulation Male Medical sciences metamizol Motor Neurons - physiology Nociceptors - drug effects Non-steroidal anti-inflammatory drugs Noxious stimulation Pain Pharmacology. Drug treatments Physical Stimulation Rats Rats, Wistar Reflex - drug effects Spinal cord Spinal Cord - cytology Wind-up Withdrawal reflexes
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