DNA Polymerase III Proofreading Mutants Enhance the Expansion and Deletion of Triplet Repeat Sequences in Escherichia coli

The influence of mutations in the 3′ to 5′ exonucleolytic proofreading ε-subunit of Escherichia coliDNA polymerase III on the genetic instabilities of the CGG·CCG and the CTG·CAG repeats that cause human hereditary neurological diseases was investigated. The dnaQ49ts and themutD5 mutations destabili...

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Veröffentlicht in:	The Journal of biological chemistry 2000-01, Vol.275 (3), p.2174-2184
Hauptverfasser:	Iyer, Ravi R., Pluciennik, Anna, Rosche, William A., Sinden, Richard R., Wells, Robert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles DNA Polymerase III - genetics DNA Repair - genetics Electrophoresis, Polyacrylamide Gel Escherichia coli Escherichia coli - genetics Exodeoxyribonuclease V Exodeoxyribonucleases - genetics Models, Genetic mutD5 gene Plasmids - metabolism Sequence Deletion Temperature Trinucleotide Repeat Expansion - genetics Trinucleotide Repeats - genetics
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