Kinetics of the early subcellular distribution of cadmium in rat hepatocytes

The kinetics of the early subcellular distribution of cadmium (Cd) was characterized in primary cultures of rat hepatocytes exposed to 10, 50 and 100 microM Cd in a serum-free WME medium for 10, 30 or 60 min. Our results demonstrate a time- and concentration-dependent increase in Cd content with the...

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Veröffentlicht in:	Biometals 2005-06, Vol.18 (3), p.255-267
Hauptverfasser:	Diep, Pham T N, Denizeau, Francine, Jumarie, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cadmium Cadmium - metabolism Cadmium - pharmacokinetics Cadmium - pharmacology Cadmium - toxicity Cells, Cultured Dose-Response Relationship, Drug Hepatocytes - drug effects Hepatocytes - metabolism Kinetics Male Metal concentrations Metallothionein - genetics Mitochondria Proteins Rats Rats, Sprague-Dawley RNA, Messenger - genetics Spectrophotometry, Atomic Time Factors
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