Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries

Quinolones are the most active oral antibacterials in clinical use and act by increasing DNA cleavage mediated by prokaryotic type II topoisomerases. Although topoisomerase IV appears to be the primary cytotoxic target for most quinolones in Gram-positive bacteria, interactions between the enzyme an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 1999-12, Vol.274 (50), p.35927-35932
Hauptverfasser:	Anderson, V E, Zaniewski, R P, Kaczmarek, F S, Gootz, T D, Osheroff, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - pharmacology Biological Evolution Ciprofloxacin - pharmacology DNA Damage DNA religation DNA Repair - drug effects DNA Topoisomerase IV DNA Topoisomerases, Type II - drug effects DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism Escherichia coli - enzymology Etoposide - pharmacology Fluoroquinolones Gram-Positive Bacteria - drug effects Kinetics Quinolones - pharmacology Staphylococcus aureus Staphylococcus aureus - enzymology Staphylococcus aureus - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!