Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases

Treatment of normal human epidermal keratinocytes (NHEK) with interferon-gamma (IFN-gamma) causes a 9-fold increase in the level of cyclooxygenase-2 (COX-2) mRNA expression. Nuclear run-off assays indicate that this induction is at least partly due to increased transcription. Activation of the epide...

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Veröffentlicht in:	The Journal of biological chemistry 1999-10, Vol.274 (41), p.29138-29148
Hauptverfasser:	Matsuura, H, Sakaue, M, Subbaramaiah, K, Kamitani, H, Eling, T E, Dannenberg, A J, Tanabe, T, Inoue, H, Arata, J, Jetten, A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphiregulin Carcinoma, Squamous Cell Cyclooxygenase 1 Cyclooxygenase 2 Dinoprostone - metabolism EGF Family of Proteins Eicosanoids - metabolism Enzyme Inhibitors - pharmacology ErbB Receptors - genetics Flavonoids - pharmacology Gene Expression Regulation, Enzymologic - drug effects Glycoproteins - metabolism Growth Substances - metabolism Humans Intercellular Signaling Peptides and Proteins Interferon-gamma - pharmacology Isoenzymes - genetics Isoenzymes - metabolism Keratinocytes Membrane Proteins Mitogen-Activated Protein Kinases - metabolism Promoter Regions, Genetic Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Regulatory Sequences, Nucleic Acid RNA, Messenger - metabolism Signal Transduction - genetics Transforming Growth Factor alpha - pharmacology Tumor Cells, Cultured
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