Translational Regulation of Ribonucleotide Reductase by Eukaryotic Initiation Factor 4E Links Protein Synthesis to the Control of DNA Replication

Ribonucleotide reductase synthesizes dNDPs, a specific and limiting step in DNA synthesis, and can participate in neoplastic transformation when overexpressed. The small subunit (ribonucleotide reductase 2 (RNR2)) was cloned as a major product in a subtraction library from eukaryotic initiation fact...

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Veröffentlicht in:	The Journal of biological chemistry 1999-12, Vol.274 (50), p.35991-35998
Hauptverfasser:	Abid, M R, Li, Y, Anthony, C, De Benedetti, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals benomyl Benomyl - pharmacology Cell Cycle - physiology CHO Cells Cloning, Molecular Cricetinae DNA Replication Eukaryotic Initiation Factor-4E Fibroblast Growth Factors - genetics Gene Expression Regulation - drug effects Hydroxyurea - pharmacology Microtubules - drug effects Microtubules - ultrastructure Ornithine Decarboxylase - genetics Peptide Initiation Factors - genetics Peptide Initiation Factors - metabolism Polyribosomes - metabolism Protein Biosynthesis Recombinant Proteins - metabolism Ribonucleotide Reductases - biosynthesis Ribonucleotide Reductases - genetics RNA, Messenger - genetics S Phase Saccharomyces cerevisiae - genetics Transcription, Genetic Transfection
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