Post-ischemic RSR13 amplifies the effect of dizocilpine on outcome from transient focal cerebral ischemia in the rat

In a recent study of focal cerebral ischemia in rats, pre-ischemic administration of the synthetic allosteric hemoglobin modifier RSR13 (2-[4-[[3,5-dimethylanilino) carbonyl] methyl] phenoxy]-2-methylproprionic acid) reduced cerebral infarct size when combined with the NMDA receptor antagonist dizoc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2000-01, Vol.853 (1), p.15-21
Hauptverfasser:	Mackensen, G.Burkhard, Nellgård, Bengt, Sarraf-Yazdi, Shiva, Franklin Dexter, Steffen, Robert P, Grocott, Hilary P, Warner, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - therapeutic use Animals Biological and medical sciences Blood Gas Analysis Body Temperature Cerebral ischemia, focal Disease Models, Animal Dizocilpine Maleate - therapeutic use Drug Synergism Hemoglobin, allosteric modification Hemoglobins - metabolism Infarction, Middle Cerebral Artery Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - physiopathology Male Medical sciences Neurologic Examination - drug effects Neurology Neuroprotective Agents - therapeutic use Propionates - therapeutic use Rat Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Vascular diseases and vascular malformations of the nervous system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!