Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption

Abstract Here we describe development of an extracorporeal hemoadsorption device for sepsis therapy that employs commercially available polysulfone or polyethersulfone hollow fiber filters similar to those used clinically for hemodialysis, covalently coated with a genetically engineered form of the...

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Veröffentlicht in:	Biomaterials 2015-10, Vol.67, p.382-392
Hauptverfasser:	Didar, Tohid F, Cartwright, Mark J, Rottman, Martin, Graveline, Amanda R, Gamini, Nazita, Watters, Alexander L, Leslie, Daniel C, Mammoto, Tadanori, Rodas, Melissa J, Kang, Joo H, Waterhouse, Anna, Seiler, Benjamin T, Lombardo, Patrick, Qendro, Elisabet I, Super, Michael, Ingber, Donald E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Advanced Basic Science Animals Anti-Bacterial Agents - therapeutic use Antibiotics Bacteria Bacterial Infections - drug therapy Bio-functional hollow fibers Blood Candida albicans CHO Cells Combined drug–device therapy for sepsis Cricetinae Cricetulus Dentistry Devices Dialysis like treatment (DLT) of sepsis Endotoxins Escherichia coli Extracorporeal Circulation Hemofiltration Humans Lipopolysaccharides Male Opsonin Proteins - therapeutic use Pathogen and LPS-endotoxin cleansgin Pathogens Rats, Wistar Staphylococcus aureus Sytematic blood infections Therapy
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