Asymmetric Vinylogous Michael Addition/Cyclization Cascade Reaction for the Construction of Diversely Structured Spiro- Oxindole Skeletons

We present the first organocatalytic asymmetric vinylogous Michael/cyclization reaction of α,α‐dicyanoalkenes with 3‐alkylideneoxindoles. A series of diversely structured spiro‐oxindole skeletons was smoothly delivered with excellent yields and stereoselectivity control (94–99% yields, >20:1 dr a...

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Veröffentlicht in:	Advanced synthesis & catalysis 2013-11, Vol.355 (16), p.3119-3123
Hauptverfasser:	Shi, Xiao-Mei, Dong, Wei-Ping, Zhu, Li-Ping, Jiang, Xian-Xing, Wang, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric catalysis Asymmetry cascade reactions Cascades Catalysis Construction dicyanoalkenes Michael addition Michael reaction organocatalysis Stereoselectivity Synthesis
Online-Zugang:	Volltext
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