Asymmetric Synthesis of cis-3,4-Disubstituted Chromans and Dihydrocoumarins via an Organocatalytic Michael Addition/ Hemiacetalization Reaction

The organocatalytic domino Michael/hemiacetalization reaction between various aldehydes and ortho‐nitrovinylphenols has been developed. Under the catalysis of diphenyl prolinol trimethylsilyl ether, cis‐3,4‐disubstituted chromanols are obtained in high to excellent yields (81–98%) and stereoselectiv...

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Veröffentlicht in:	Advanced synthesis & catalysis 2010-11, Vol.352 (17), p.2869-2874
Hauptverfasser:	Enders, Dieter, Wang, Chuan, Yang, Xuena, Raabe, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4‐dihydrocoumarins 4-dihydrocoumarins Aldehydes Asymmetry Catalysis chromans Ethers hemiacetalization Michael addition Michael reaction organocatalysis Oxidation Pyridinium chlorochromate Stereoselectivity Synthesis
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