Ligand-free Cu2O-catalyzed cross coupling of nitrogen heterocycles with iodopyridines
A practical and efficient strategy has been developed for the cross coupling of nitrogen heterocycles with halopyridines using ligand-free Cu2O as catalyst and Cs2CO3 as the base. The protocol is applicable to a series of highly functionalised heterocycles, such as 7-azaindole, indazole, indole, imi...
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| Veröffentlicht in: | Tetrahedron 2013-09, Vol.69 (35), p.7279-7284 |
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| container_title | Tetrahedron |
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| creator | Teo, Yong-Chua Yong, Fui-Fong Sim, Shirlyn |
| description | A practical and efficient strategy has been developed for the cross coupling of nitrogen heterocycles with halopyridines using ligand-free Cu2O as catalyst and Cs2CO3 as the base. The protocol is applicable to a series of highly functionalised heterocycles, such as 7-azaindole, indazole, indole, imidazole, pyrrole and pyrazole, affording the N-heteroaryl derivatives in high yields (up to 96%).
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| doi_str_mv | 10.1016/j.tet.2013.06.095 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Tetrahedron, 2013-09, Vol.69 (35), p.7279-7284 |
| issn | 0040-4020 1464-5416 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1744708925 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | CATALYSTS COPPER OXIDE Copper-catalyzed Cross coupling CUPROUS OXIDE Derivatives Imidazole Iodopyridines LIGANDS N-Heteroarylation NITROGEN Nitrogen heterocyles Pyrazole Pyrroles Strategy Tetrahedrons |
| title | Ligand-free Cu2O-catalyzed cross coupling of nitrogen heterocycles with iodopyridines |
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