Synthesis of N,4-diaryl substituted ?-lactams via Kinugasa cycloaddition/rearrangement reaction

The methodology of construction of N,4-diaryl substituted [beta]-lactam framework, based on the Kinugasa cycloaddition/rearrangement sequence is presented. The series of protected chiral propargyl alcohols was treated with diaryl nitrones to afford mainly the cis-I adduct, providing direct access to...

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Veröffentlicht in:	Tetrahedron 2012-12, Vol.68 (52), p.10806-10817
Hauptverfasser:	Michalak, Micha, Stodulski, Maciej, Stecko, Sebastian, Wonica, Magdalena, Staszewska-Krajewska, Olga, Kalicki, Przemysaw, Furman, Bartomiej, Frelek, Jadwiga, Chmielewski, Marek
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Alcohols Cycloaddition Derivatives Hydroxyl groups Propargyl alcohol Rings (mathematics) Stereochemistry
Online-Zugang:	Volltext
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