Three-component synthesis of 2-amino-3-cyano-5-oxo-4-perfluoroalkyl-5,6,7,8-tetrahydro-4H-chrom e ne derivatives
A variety of 2-amino-3-cyano-5-oxo-4-perfluoroalkyl-5,6,7,8-tetrahydro-4H-chrom e ne derivatives were achieved via a one-pot, three-component reaction from easily available methyl 2-perfluoroalkynoate, malononitrile (or ethyl cyanoacetate), and diverse cyclic 1,3-diketones. Moderate to good yields (...
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| Veröffentlicht in: | Tetrahedron 2013-07, Vol.69 (30), p.6121-6128 |
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| container_issue | 30 |
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| container_title | Tetrahedron |
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| creator | Bian, Linglin Xu, Jiechao Xie, Liqing Chen, Jie Deng, Hongmei Shao, Min Ding, Tianling Zhang, Hui Cao, Weiguo |
| description | A variety of 2-amino-3-cyano-5-oxo-4-perfluoroalkyl-5,6,7,8-tetrahydro-4H-chrom e ne derivatives were achieved via a one-pot, three-component reaction from easily available methyl 2-perfluoroalkynoate, malononitrile (or ethyl cyanoacetate), and diverse cyclic 1,3-diketones. Moderate to good yields (up to 93%) were obtained in the presence of catalytic methylamine. This process went through a tandem Michael additionacyclization reaction and was mild and easily performed. |
| doi_str_mv | 10.1016/j.tet.2013.05.053 |
| format | Article |
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Moderate to good yields (up to 93%) were obtained in the presence of catalytic methylamine. 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| ispartof | Tetrahedron, 2013-07, Vol.69 (30), p.6121-6128 |
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| source | Elsevier ScienceDirect Journals |
| subjects | Catalysis Catalysts Derivatives Malononitrile Synthesis Tetrahedrons |
| title | Three-component synthesis of 2-amino-3-cyano-5-oxo-4-perfluoroalkyl-5,6,7,8-tetrahydro-4H-chrom e ne derivatives |
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